toxicology

What is the SMAD Signalling Pathway – and why is it Important for Divergent Bodies?

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© Alexandra Chambers | Neurotopia CIC | January 2026 In connective tissue divergence, immune sensitivity, or genomically divergent bodies, fibrosis is one of the most damaging long-term outcomes. Here I will explain what actually drives that scarring process deep in the tissues. At the heart of the fibrosis response is a powerful molecular communication route […]

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The Spectrum of Mobility: Can a Person be Both Hypermobile and Hypomobile?

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© Alexandra Chambers | Neurotopia CIC | January 2026 While mainstream narratives often frame connective tissue profiles in binary terms – either hypermobile or (rarely) hypomobile – the lived reality is often far more complex. In truth, it is biologically and mechanistically possible for different parts of the same body to express divergent mobility traits.

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Endometriosis: not the Cause, but the Expression

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© Alexandra Chambers | Neurotopia CIC | January 2026 Mainstream science has just “discovered” what many of us have known for years: that endometriosis is connected to more than the reproductive system. New research from Penn State finds that people with endometriosis have blunted blood pressure responses to physical stress – contradicting their initial hypothesis

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Another Piece of a Self-Made Jigsaw

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© Alexandra Chambers | Neurotopia CIC | December 2025 The recent study from Yale (linked at the bottom of the post) claiming that autistic adults have reduced mGlu5 receptor availability may feel like a breakthrough to some. However, it’s another fragment in a long trail of fragmented science. For decades, autistic people have been used

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Strengthening the Blood-Brain Barrier & Connective Tissue in Divergent Bodies

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© Alexandra Chambers | Neurotopia CIC | December 2025 Disclaimer: Every individual’s biology is unique. Genetic variation, methylation status, nutrient processing, and environmental factors all influence what supports or disrupts internal systems. What strengthens one person’s blood–brain barrier may overwhelm another’s. This article is written from a divergent genomics perspective, with emphasis on terrains that

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Connective Tissue, Sensory Terrain, and the Hidden Architecture of Perception

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©Alexandra Chambers | Neurotopia CIC | December 2025 All research is available for PDF digital download on: https://studio.buymeacoffee.com/extras and all money goes directly to Neurotopia CIC to fund further research, thank you. Following the response to the previous exploration of connective tissue in the eyes and ears, this post continues the sensory map through the

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Autism, or Pathologised Evolution?

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©Alexandra Chambers | Neurotopia CIC | October 2025 All research is available for PDF digital download on: https://studio.buymeacoffee.com/extras and all money goes directly to Neurotopia CIC to fund further research, thank you. Abstract Autism is widely classified as a neurodevelopmental disorder, yet accumulating evidence suggests it represents a modern diagnostic label applied to evolutionarily conserved,

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Rethinking Folic Acid Fortification: a pharmacogenomic and policy-based reappraisal of neural tube defect trends

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©Alexandra Chambers | Neurotopia CIC | September 2025 All research is available for PDF digital download on https://studio.buymeacoffee.com/extras and all money goes directly to Neurotopia CIC to fund further research, thank you. Abstract This investigative research critically re-evaluates the widely accepted attribution of reduced neural tube defect (NTD) rates in Canada to folic acid fortification.

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