pharmacogenomics

What is the SMAD Signalling Pathway – and why is it Important for Divergent Bodies?

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© Alexandra Chambers | Neurotopia CIC | January 2026 In connective tissue divergence, immune sensitivity, or genomically divergent bodies, fibrosis is one of the most damaging long-term outcomes. Here I will explain what actually drives that scarring process deep in the tissues. At the heart of the fibrosis response is a powerful molecular communication route […]

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The Spectrum of Mobility: Can a Person be Both Hypermobile and Hypomobile?

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© Alexandra Chambers | Neurotopia CIC | January 2026 While mainstream narratives often frame connective tissue profiles in binary terms – either hypermobile or (rarely) hypomobile – the lived reality is often far more complex. In truth, it is biologically and mechanistically possible for different parts of the same body to express divergent mobility traits.

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My Perspective on Neurodivergence: Inherited and Acquired, Biological and Political

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© Alexandra Chambers | Neurotopia CIC | January 2026 I want to take a moment to be clear about where I stand when it comes to neurodivergence – especially in relation to inherited vs acquired forms, and how I understand their biological and social dimensions. Neurodivergence is Real – Even When it’s not Diagnosed The

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Another Piece of a Self-Made Jigsaw

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© Alexandra Chambers | Neurotopia CIC | December 2025 The recent study from Yale (linked at the bottom of the post) claiming that autistic adults have reduced mGlu5 receptor availability may feel like a breakthrough to some. However, it’s another fragment in a long trail of fragmented science. For decades, autistic people have been used

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Strengthening the Blood-Brain Barrier & Connective Tissue in Divergent Bodies

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© Alexandra Chambers | Neurotopia CIC | December 2025 Disclaimer: Every individual’s biology is unique. Genetic variation, methylation status, nutrient processing, and environmental factors all influence what supports or disrupts internal systems. What strengthens one person’s blood–brain barrier may overwhelm another’s. This article is written from a divergent genomics perspective, with emphasis on terrains that

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Autism, or Pathologised Evolution?

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©Alexandra Chambers | Neurotopia CIC | October 2025 All research is available for PDF digital download on: https://studio.buymeacoffee.com/extras and all money goes directly to Neurotopia CIC to fund further research, thank you. Abstract Autism is widely classified as a neurodevelopmental disorder, yet accumulating evidence suggests it represents a modern diagnostic label applied to evolutionarily conserved,

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Rethinking Folic Acid Fortification: a pharmacogenomic and policy-based reappraisal of neural tube defect trends

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©Alexandra Chambers | Neurotopia CIC | September 2025 All research is available for PDF digital download on https://studio.buymeacoffee.com/extras and all money goes directly to Neurotopia CIC to fund further research, thank you. Abstract This investigative research critically re-evaluates the widely accepted attribution of reduced neural tube defect (NTD) rates in Canada to folic acid fortification.

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